Acosil
Engineered for Peak Performance
Acosil Chromatography Columns
Acosil HPLC columns are high-performance chromatography columns designed for reproducible separations in pharmaceutical, biotech, food, and research laboratories.
Acosil offers C18, C8, AQ, Chiral, UHPLC, Preparative, Carbohydrate, Specialty, and Ghost Eliminator columns.
Acosil C18 columns are reversed-phase columns used for API analysis, impurity profiling, and routine QC testing.
Acosil Chiral columns are designed for enantiomer separation and optical purity determination.
Ghost Eliminator columns remove system ghost peaks caused by solvents, tubing, and contamination.
Yes. Acosil columns are designed for batch consistency, reproducibility, and long-term supply.
Acosil preparative columns are designed for purification and isolation of target compounds at higher sample loads than analytical columns. They are commonly used during process development, impurity isolation, and scale‑up work where milligram to gram quantities are required. These columns focus on recovery, throughput, and reproducibility rather than only analytical resolution.
Preparative columns have larger internal diameters and higher loading capacity compared to analytical columns. While analytical columns focus on resolution and sensitivity, preparative columns are optimized for compound recovery and scalability. Method transfer from analytical to preparative requires maintaining selectivity while adjusting flow and loading.
Yes, Acosil preparative columns are suitable for scaling up analytical separations to preparative purification. By keeping the same stationary phase chemistry, methods can be transferred with predictable selectivity. This makes them useful for R&D, pilot studies, and routine purification.
Acosil carbohydrate columns are designed for the separation of sugars, sugar alcohols, organic acids, and related polar compounds. They are widely used in food, beverage, pharmaceutical excipient, and fermentation analysis. These columns typically operate under aqueous or highly polar mobile phase conditions.
Calcium‑form (Ca++) carbohydrate columns separate sugars based on ligand exchange and size‑related interactions. They are commonly used for profiling glucose, fructose, sucrose, lactose, and similar carbohydrates. Such columns are often paired with refractive index or ELSD detection.
Yes, Acosil carbohydrate columns are suitable for routine quality control and batch release testing. They offer stable retention, reproducible performance, and compatibility with commonly used detectors. This makes them reliable for long‑term use in regulated laboratory environments.
Acosil UHPLC columns are designed for ultra-high performance liquid chromatography systems operating at higher pressures. They use smaller particle sizes to deliver higher efficiency, sharper peaks, and faster separations. These columns are suitable for advanced analytical and research applications.
UHPLC columns typically use sub‑2 µm or small particle sizes compared to conventional HPLC columns. This improves resolution and reduces analysis time, but requires systems capable of handling higher backpressure. UHPLC columns are ideal when speed and efficiency are critical.
Yes, Acosil UHPLC columns are compatible with LC–MS applications when used with MS‑friendly mobile phases. Their low bleed characteristics and stable stationary phases help maintain clean mass spectra. This makes them suitable for quantitative and qualitative MS workflows.
UHPLC columns are commonly used for impurity profiling, bioanalysis, metabolite identification, and high‑throughput screening. They are widely adopted in pharmaceutical R&D, clinical research, and analytical laboratories. Faster run times improve productivity without compromising data quality.
Yes, many HPLC methods can be transferred to UHPLC by maintaining the same stationary phase chemistry. Flow rates, injection volumes, and column dimensions are adjusted to manage pressure and efficiency. Proper method verification ensures consistent performance after transfer.