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Acosil
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Acosil Chromatography Columns.

Analytical HPLC Column
Analytical Columns
Technical Data – Acosil 110 C18
Pore Size110 Å
Pore Volume1.1 cm³/g
Surface Area 400 m²/g
Carbon Content 17.0 %
pH-StabilitypH 2–11
EndcappingComplete
Silica Purity> 99.999 %
Metal Impurities< 5 ppm
UHPLC / LCMS Column
UPLC / LCMS Columns
Technical Data – Acosil 100 C18
Pore Size100 Å
Pore Volume1.1 cm³/g
Surface Area 350 m²/g
Carbon Content 19.0 %
pH-StabilitypH 2–11
EndcappingComplete
Silica Purity> 99.999 %
Metal Impurities< 5 ppm
Chiral Column
Chiral Columns
Technical Data – AcoChiral
AcoChiral is a bonded chiral stationary phase based on cellulose 3,5-dichlorophenylcarbamate, offering proven and reliable chiral selectivity. AcoChiral columns are manufactured using high-quality Chiral media to deliver excellent efficiency, reproducibility, and robustness. Available in 3 µm, 5 µm, 10 µm, and 20 µm particle sizes, they support both analytical and preparative applications. AcoChiral provides comprehensive method development and technical support to ensure optimal separations. Designed for consistency and performance, AcoChiral columns deliver an advanced and dependable experience for chiral chromatographic analysis.
Carbohydrate and Specialty Column
Carbohydrate & Specialty Columns
Technical Data – Acosil Ca++
Acosil Ca++ columns are packed with calcium-type sulfonated styrene–divinylbenzene spherical particles featuring an 8% Ca²⁺ crosslinking degree. The column offers excellent pressure resistance, pH stability, and high separation efficiency with broad selectivity. Complex mixtures can be separated using a simple mobile phase, typically water, with precise temperature control ensuring consistent performance. Acosil Ca++ delivers highly repeatable retention times and resolution, proven through rigorous batch-to-batch and column-to-column validation. Its long service life and reproducibility over hundreds of runs reduce data variability and lower costs associated with frequent column replacement..
Preparative Column
Preparative Columns
Technical Data – Acosil 110 C18
Pore Size110 Å
Pore Volume1.1 cm³/g
Surface Area 400 m²/g
Carbon Content 17.0 %
pH-StabilitypH 2–11
EndcappingComplete
Silica Purity> 99.999 %
Metal Impurities< 5 ppm
Ghost Eliminator Column
Ghost Eliminator Columns
Technical Data – Ghost Eliminator
In gradient HPLC analysis using buffer salts or acidic additives, unwanted ghost peaks may appear and interfere with accurate detection of target analytes, particularly in trace-level analysis. These peaks often originate from impurities present in the mobile phase and increase chromatographic complexity. Ghost Eliminator is designed to selectively remove such impurities directly within the LC system, without altering mobile phase composition or separation conditions. This helps prevent false peaks, simplifies chromatograms, and reduces method development effort. The advanced second-generation Ghost Eliminator is fully compatible with ion-pair reagents and does not adsorb them, ensuring reliable performance across a wide range of applications.

Choosing Acosil Columns – FAQs

How do I choose the right HPLC column?

Column selection depends on analyte polarity, chemistry, mobile phase, detection method, and required selectivity.

What information is needed to recommend an equivalent column?

Share existing column part number, dimensions, particle size, mobile phase, and application details.

Can one column be used for multiple methods?

Sometimes yes, but column selection should be optimized per method to ensure resolution and robustness.

Do Acosil columns support method transfer?

Yes. Acosil columns can be used for method transfer after appropriate verification and system suitability testing.

Are guard columns recommended?

Guard columns are recommended to protect analytical columns and extend column lifetime.

Choosing Acosil Columns – Product FAQs

How do I choose the right Acosil HPLC column?

Selecting the right Acosil column depends on analyte polarity, molecular structure, and required selectivity. Mobile phase composition, pH range, and detection technique also influence column choice. Matching these factors helps achieve reliable retention, resolution, and method robustness.

What information is required to recommend an equivalent column?

To recommend an equivalent column, information such as existing column part number, dimensions, particle size, stationary phase chemistry, mobile phase, and application details are important. This ensures performance equivalence and smooth method transfer.

Can Acosil columns be used for method transfer and validation?

Yes, Acosil columns can be used for method transfer when chemistry and dimensions are matched correctly. Proper system suitability testing and verification are recommended before routine use. This approach supports validated and regulated analytical workflows.

Should I use a guard column with Acosil analytical columns?

Guard columns are recommended to protect analytical columns from particulates and strongly retained contaminants. They help extend column lifetime and maintain consistent performance. This is especially useful in routine QC and complex sample matrices.

Can one Acosil column be used for multiple applications?

In some cases, a single column chemistry may support multiple applications. However, optimal performance is achieved when the column is selected specifically for the analyte and method. Dedicated column selection improves resolution, reproducibility, and column life.

Acosil Column Families – Product Overview

Liquid Chromatography Columns

Acosil liquid chromatography columns include C18, C8, AQ, C30, and related reversed‑phase chemistries. These columns are designed for routine analytical separations, impurity profiling, and stability studies. They offer reproducible retention, stable selectivity, and compatibility with common HPLC systems.

UHPLC / LC–MS Columns

Acosil UHPLC and LC–MS columns are engineered for high‑pressure operation and efficient separations. Smaller particle sizes enable higher resolution and faster run times while maintaining robustness. These columns are suitable for MS‑sensitive applications when used with appropriate mobile phases.

Chiral Columns

Acosil chiral columns are used to separate enantiomers and stereoisomers in pharmaceutical analysis. They support optical purity testing, chiral impurity profiling, and stereoselective method development. These columns provide consistent chiral selectivity for regulated and research applications.

Carbohydrate & Specialty Columns

Acosil carbohydrate and specialty columns are designed for sugars, sugar alcohols, organic acids, and polar compounds. They are widely used in food, beverage, pharmaceutical excipient, and fermentation analysis. Stable performance under aqueous conditions makes them suitable for routine QC testing.

Preparative Columns

Acosil preparative columns are intended for compound purification and isolation at higher sample loads. They are commonly used during process development and scale‑up from analytical methods. These columns focus on recovery, throughput, and reproducibility rather than only analytical sensitivity.

Ghost Eliminator & Guard Columns

Acosil Ghost Eliminator columns are used to remove system‑derived ghost peaks and baseline disturbances. Guard columns protect analytical columns from particulates and strongly retained contaminants. Together, they help improve system cleanliness, column lifetime, and method reliability.